Multi-column chromatography (MCC)
Multi-column chromatography (MCC) is an innovative downstream processing (DSP) method gaining adoption for the purification of biological targets.
As opposed to conventional batch chromatography methods, MCC continuously processes feedstock, and in turn continuously generates purified target molecules. This is accomplished by parallel operation of multiple comparably small columns. As a result, MCC dramatically raises process productivity, which translates to resin savings of 80% or greater!
How it works. The art of Multi-Column Chromatography
Whether you call it simulated moving bed (SMB), continuous, multi-step, or multi-column chromatography, we at Tosoh Bioscience are your global partner to intensify your chromatography process. For over a decade, customers in various industries around the world have used Octave systems to purify their solutions.
Success stories: Real life applications in pharma industry
The countercurrent flow created by MCC enables extremely efficient utilization of solid and liquid phases. In single-column systems, separation actually occurs in a small portion of the column at any one time, with the rest of the column performing no function other than occupying solvent and broadening bands. With MCC, typically 50-70% of the solid phase is engaged in the separation zone, while the rest of the adsorbent material is being prepared for the next cycle of separation. Moreover, MCC provides essentially an “infinite” column bed length without the costs associated with obtaining, operating, and maintaining large single columns.
The details: Our versatile Octave MCC systems
Get to know our Octave System solutions for either pre-GMP or GMP-ready purposes.
All under control: Our intuitive software packages
Our instruments are controlled by intuitive software packages, while the unified ProComposer
method-generating software package guides you from method development and proof of concept through to scale-up of highly efficient MCC processes.