Process Development Tools
Developing a purification process for a biologic target molecule is a complex task of balancing product purity with process robustness while minimizing the number of unit operations. Future process and scale up requirements should be considered right from the start of method development. Resin screening and selection is the first step in DSP development of chromatographic unit operations. Due to the diversity in available ligand chemistries and base matrices offered by different vendors it is recommended to screen a certain number of resins to select the most suited resin for a given target molecule. Today robotic systems allow the high throughput screening of a broad range of resins and a faster method development.
Tosoh Bioscience offers a wide variety of screening tools for TOYOPEARL, TSKgel, and Ca++Pure-HA process media. They include 96-well plate kits, RoboColumns for high throughput process development, and SkillPak pre-packed columns