TARGET MOLECULES

Biosimilars

Biosimilars

Within the field of biologics, biosimilars (or follow-on-biologics) and biobetters are gaining increasing attention. In order to improve process economics for these products a thorough optimization of the manufacturing process is a must. Tosoh Bioscience offers a variety of (U)HPLC columns for protein analysis and TOYOPEARL and TSKgel media for the purification of recombinant proteins.

 


TSKgel columns are used in a broad range of typical analysis in R&D and production of recombinant proteins: 
Aggregate and fragment content by Gel Filtration Chromatography (GFC) » 
Glycan mapping by Hydrophilic Interaction Liquid Chromatography (HILIC) »   
Charge variants through Cation Exchange Chromatography »  
Reversed Phase analysis of proteins »  
Reversed Phase analysis of peptide digests » 

 

TOYOPEARL and TSKgel media can be applied at every stage of a typical protein purification platform: 
Capturing from cell culture media through salt tolerant Anion Exchange Chromatography »  
Host cell protein reduction through Cation Exchange Chromatography »   
DNA, endotoxin, and virus removal through Anion Exchange Chromatography »   
Aggregate removal through Mixed-Mode Chromatography »