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tosoh bioscience
chromatography
catalog
Introduction
Tosoh Bioscience is a major supplier of liquid chromatography pro-
ducts worldwide, particularly to the pharmaceutical and biotech-
nology industries. The company distributes and supports products
manufactured by our parent company, Tosoh Corporation, which has
offices and manufacturing facilities in Japan. Located in Griesheim,
Germany, Tosoh Bioscience GmbH provides sales and service to cus-
tomers in Europe, the Middle East, South Asia and Africa.
This Chromatography Products Catalog describes analytical and
semi-preparative TSKgel
®
prepacked columns for each of the
major chromatography modes. It also gives a short overview of
TOYOPEARL
®
and TSKgel bulk resins for laboratory scale purifica-
tions, as well as ToyoScreen process development columns.
TSKgel and TOYOPEARL products are used for the analysis, isolation
and purification of proteins, peptides, DNA, oligonucleotides, anti-
biotics and other small molecular weight compounds. Our products
are known for their ability to withstand high pressure, their robust
chemical stability, and their superior performance for the recovery,
concentration and purification of biomolecules.
What’s new
TSKgel SuperSW mAb/UltraSW mAb columns
TSKgel SuperSWmAb HTP columns support high throughput antibody
analysis. Packed in 4.6 x 150 mm UHPLC column hardware they were
engineered to enable an easy transfer of SEC methods, which have
been developed on conventional gel filtration columns, to fast UHPLC
analysis. TSKgel SuperSW mAb HR, designed for high resolution
monoclonal analysis, is packed in columns featuring the conventional
dimensions for HPLC gel filtration columns. This allows for superior
resolution between fragments, monomers, and aggregates. TSKgel
UltraSW Aggregate covers the range of higher molecular weights
and provides a very good separation of antibody dimers and higher
aggregates. It is based on smaller silica particles with slightly larger
pore size than the SuperSW mAb columns.
EcoSEC High Temperature Instrument
Tosoh Bioscience launched a compact high temperature (HT) system
for GPC analysis. EcoSEC-HT, the all-in-one GPC/SEC system,
provides stable thermostatization up to 220° C. Autoinjector, pumps,
and a dual-flow RI detector are integrated in a compact design.
The optional sample processing unit can process up to 24 samples.
The TSKgel GMH
HR
- HT2 GPC columns were developed to ideally
complement the EcoSEC-HT.
TOYOPEARL AF-rProtein A HC-650F resin
Tosoh Bioscience introduces new high capacity Protein A affinity
resin. It is specifically designed for efficient purifications of mAbs.
It is a rigid, alkaline resistant protein A affinity resin that offers
the largest binding capacity for IgG of all protein A media currently
available on the market.
TOYOPEARL MX-Trp-650 resin
TOYOPEARL MX-Trp-650M is a multimodal cation exchange resin with
unique selectivity and high recovery. It provides high protein binding
capacities and tolerates high conductivity feedstocks. Its ligand, the
amino acid tryptophan, provides ionic and hydrophobic interactions.
This new mixed-mode resin is well-suited for intermediate and
polishing steps, such as aggregate removal in antibody purification,
and for the purification of targets that are difficult to purify using
common purification platforms.
