Toyopearl GigaCap S-650M has excellent base stability in 1.0 mol/L NaOH and shows robust clean in place properties with minimal loss of capacity after 50 x 1 hour cycles of caustic exposure using 1.0 mol/L NaOH.
 Alkaline Stability |
evaluation period
(soaking) |
week |
0 |
1 |
3 |
5 |
| IEC capacity |
meq/ml |
0.159 |
0.157 |
0.158 |
0.156 |
hIgG-DBC (10%
breakthrough) |
mg/ml-gel |
143 |
144 |
140 |
135 |
| hIgG recovery |
% |
99 |
101 |
100 |
99 |
|
| Clean in place stability |
Column exposed to 50 cycles of 1.0 mol/L NaOH at 280 cm/hr and the dynamic binding capacity of lysozyme was determined (exposure time at least 1 hour per cycle)
| |
Prior to NaOH |
After 50 cycles |
|
Toyopearl
GigaCap S-650M |
167 mg/ml-resin |
163 mg/ml-resin |
|
|