TSKgel HIC packings consist of polymethacrylate base material and a choice of three ligands (butyl, ether and phenyl) with varied hydrophobicities from low to high, respectively. 

The polymethacrylate base resin for the ether and phenyl columns is a porous material with a 1000 Å pore size and 1,000,000 Da exclusion limit, offering high capacity and high sample loads. The TSKgel Butyl-NPR features a non-porous support in which only the surface of the bead is available for adsorption. Shorter run times and excellent recovery make the butyl column an optimal choice for high throughput or QC analysis. See the figure below for a comparison between the three column types.